Letter to the Editor. Claude Bernard was right: hormones may be produced by "non-endocrine" cells.
نویسندگان
چکیده
In recent years attention of the specialists in different fields of biomedicine has focus on an unusual phenomenon, i.e., many so-called “non-endocrine” cells in living organism produce hormones. In addition to neurons and some types of lymphocytes for which such ability was shown earlier [1–2], a large number of other cells significantly extend this list today. Among them, mast cells, natural killer cells, eosinophilic leukocytes, endothelial cells, thymic epithelial cells, monocytes, platelets, chondrocytes, osteocytes, placental trophoblasts and amnion cells, ovarian Leydig cells, endometrial cells, retinal photoreceptors and amacrine cells, Merkel cells in skin, Paneth cells, and macrophages. The spectrum of hormonal substances produced by these cells is extremely wide and includes serotonin, melatonin, catecholamines, histamine, endorphins, endothelin, matrilysin, natriuretic peptide, vasoactive intestinal peptide, vasopressin, oxytocin, thymosins, insulin and insulin-like substance, somatostatin, prolactin, ACTH, leptin and others [3–7]. This list could be further extended if organs producing nitric oxide (NO) were included. NO also is considered as a gaseous hormonal substance [8]. Moreover, many different peptide complexes (so called “cytomedines”) which are able to regulate intercellular communications within of small particularized cellular populations, were evoked from almost all tissues [9]. L E T T E R
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ورودعنوان ژورنال:
- Neuro endocrinology letters
دوره 21 3 شماره
صفحات -
تاریخ انتشار 2000